- 【SCI2区通讯作者宋晓锋】Poly(N-isopropylacrylamide-co-vinyl acetate)/poly(l-lactic acid) composite
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- 所属单位：化学工程学院
- 发表刊物：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 项目来源：其他课题
- 摘要：Poly(L-lactic acid) (PLLA) has been attracted increasing interesting in biomedicine and tissue engineering. However, its hydrophobicity can bring about some adverse effects on protein adsorption and downstream cell adhesion. Poly(N-isopropylacrylamide) (PNIPAm) is a well-known water-soluble polymer which exhibits a hydrophobic-hydrophilic phase transition in aqueous solution upon heating. In this work, a series of P(NIPmco-VAc) polymers have been synthesized by using NIPA and vinyl acetate (VAc) as raw materials to insert into PLLA. The results show that the lower critical solution temperature (LCST) of synthesized polymer is 33–34 ◦C. When the molar ratio of NIPA to VAc and the blend ratio of synthesized polymer to PLLA are 0.76/1 and 20 wt%,respectively, the hydrophilicity of composite enhances significantly at room temperature. In particular, the composite exhibits thermoresponsive wettability below and above the LCST. Although the water contact angle presents a systematic increase with temperature increasing, it doesn’t pass through the real hydrophobic domain because the conformational transition of wettable PNIPAm segment is subjected to intramolecular PVAc segment and extramolecular PLLA chain. Moreover, the synthesized polymer also offsets the brittleness of PLLA. So the method provides thermoresponsive wettability for PLLA and builds a platform for developing intelligent PLLA.
- 合写作者：夏文龙,宋晓峰
- 第一作者：宋晓峰
- 论文类型：期刊论文
- 卷号：636
- 页面范围：1
- 是否译文：否
- 发表时间：2022-01-01
