- Hydroxyapatite cross-linked in situ polyvinyl alcohol hydrogel for bionic calcified cartilage layer
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- 所属单位：化学工程学院
- 发表刊物：Colloids and Surfaces B: Biointerfaces
- 项目来源：省、市、自治区科技项目
- 关键字：composite hydrogel
- 摘要：Many tissue engineering constructs have been investigated for repairing the calcified cartilage layer in the recent years, but engineering a consistent and stable interface to facilitate a graft-to-bone fixation remains a concern. In the work, hydroxyapatite (HA) is modified by diisocyanate (HDI) and integrated with polyvinyl alcohol (PVA) to prepare the hydrogel. The IR shows that HDI is grafted onto HA and helps HA to cross-link in situ in the PVA gel network. When the mass ratio of HA/PVA is 3.5 wt%, the swelling rate in the PBS of different pH reduced with time prolong, and the hydrogel takes on good swelling resistance. The tensile strength and toughness are 1890 KPa and 264 KJ/m-3, respectively, while the compression strength reaches 1125 KPa at compressive strain of 60%. The hydrogel not only is well durable via continuous 100 rounds of compression-recovery, but also has excellent bioactivity. The work will provide a platform for developing multifunctional soft tissue scaffold.
- 合写作者：曲瑞,宋晓峰
- 第一作者：宋晓峰
- 论文类型：期刊论文
- 卷号：230
- 页面范围：1
- 是否译文：否
- 发表时间：2023-08-07
