Paper Publications

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Affiliation of Author(s):化学与生命科学学院

Teaching and Research Group:生物技术教研室

Journal:Biomaterials

Funded by:“９７３”计划

Key Words:Cancer cell targeting; Imaging; Drug delivery; Radiotherapy

Abstract:A dual-ligand gold nanoparticle (DLGNP) was designed and synthesized to explore the therapeutic benefits of multivalent interactions between gold nanoparticles (GNPs) and cancer cells. DLGNP was tested on human epidermal cancer cells (KB), which had high expression of folate receptor. The cellular uptake of DLGNP was increased by 3.9 and 12.7 folds compared with GNP-folate or GNP-glucose. The enhanced cell recognition was due to multivalent interactions between both ligands on GNPs and cancer cells as shown by the ligand competition experiments. Furthermore, the multivalent interactions increased contrast between cells with high and low expression of folate receptors. The enhanced cell recognition enabled DLGNP to kill KB cells under X-ray irradiation at a dose that was safe to folate receptor low-expression (such as normal) cells. Thus DLGNP has the potential to be a cancer-specific nano-theranostic agent.

First Author:li xi

Indexed by:Journal paper

Volume:32

Issue:10

Page Number:1

Number of Words:1

ISSN No.:0142-9612

Translation or Not:no

Date of Publication:2011-01-12