- 【SCI通讯】PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery
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- 所属单位：化学工程学院
- 发表刊物：molecules
- 项目来源：自选课题
- 关键字：amphiphilic copolymer; hydrolyzable polyurea; micelle; controlled drug delivery; cancer chemotherapy
- 摘要：In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) (PEG) was synthesized for the controlled delivery of the antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.
- 第一作者：杨亚楠
- 论文类型：期刊论文
- 页面范围：1
- 是否译文：否
- 发表时间：2019-04-18
