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Affiliation of Author(s):化学与生命科学学院

Teaching and Research Group:生物工程教研室

Journal:Bulgarian Chemical Communications

Funded by:自选课题

Key Words:Voriconazole; LC-MS/MS; Human plasma

Abstract:rapid and sensitive method for the determination of voriconazole in human plasma was developed. Voriconazole and the internal standard were extracted from plasma samples by liquid–liquid extraction with 2 ml of diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: diethyl ether: dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v)dichloromethane (60: 40, v/v) dichloromethane (60: 40, v/v). The chromatographic separation was accomplished isocratically on a 150×4.6 mm, 5 &#61549;m Zorbax extend C18 column at a flow rate of 0.7 mL/min. Detec Detection by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass tion by electrospray positive ionization mass spectrometry in the multiplespectrometry in the multiplespectrometry in the multiple spectrometry in the multiple spectrometry in the multiplespectrometry in the multiplespectrometry in the multiplespectrometry in the multiple spectrometry in the multiplespectrometry in the multiplespectrometry in the multiplespectrometry in the multiplespectrometry in the multiplespectrometry in the multiple spectrometry in the multiple spectrometry in the multiplespectrometry in the multiplespectrometry in the multiple spectrometry in the multiple -reaction monitoring modereaction monitoring mode reaction monitoring mode reaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring mode reaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring modereaction monitoring mode was completed within 3.2 min. Linearity was over the the the the concentration range concentration range concentration range concentration range concentration range concentration range concentration range concentration range concentration range concentration range concentration range concentration range 20-2000 ng/ml with ng/ml with ng/ml with ng/ml with ng/ml with ng/ml with ng/ml with ng/ml with ng/ml with a limit of detection limit of detection oflimit of detection limit of detection oflimit of detection oflimit of detection oflimit of detection oflimit of detection limit of detection limit of detection oflimit of detection oflimit of detection oflimit of detection oflimit of detection 5 ng/mlng/mlng/mlng/mlng/ml. Intra- and inter-day precision measured as relative standard deviation was <4.40% and <5.44%, respectively. The method was applied in a bioequivalence study of two tablet formulations of voriconazole.

First Author:tengguosheng

Indexed by:Journal paper

Volume:Volume 48

Issue:Number 1

Page Number:1

ISSN No.:0324-1130

Translation or Not:no

Date of Publication:2016-01-10