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所属单位：化学与生命科学学院

教研室：化学教研室

发表刊物：Journal of Materials Chemistry B

项目来源：省、市、自治区科技项目

摘要：Theranostic agents that integrate diagnostic and therapeutic modalities have drawn extensive attention due to their ability to deliver real-time imaging-guided tumor treatment. Herein, a novel core–shell polydopamine (PDA)-based theranostic agent (PDA@TA–Fe) was fabricated via a two-step strategy. Upon 808 nm and 1064 nm laser irradiation, this agent exhibited high photothermal conversion efficiencies of 29% and 41%, respectively. After endocytosis into tumor cells, the TA–Fe shell of PDA@TA–Fe gradually disintegrated in the weakly acidic tumor microenvironment (TME), and released the TA as an acidity-activated reductant that could reduce Fe3+ to Fe2+. Subsequently, the generated Fe2+ reacted with H2O2 to generate toxic hydroxyl radicals (OH) via the Fenton reaction, which induced the apoptosis of tumor cells and achieved the chemodynamic therapy (CDT). The heat produced by photothermal therapy (PTT) accelerated the OH generation to achieve a synergetic effect of CDT/PTT. In vivo tumor-xenograft imaging and therapeutic assays demonstrated obvious contrast enhancement at the tumor site in the T1/T2-weighted MR imaging and efficient tumor suppression achieved after the intravenous injection of this agent because of the enhanced permeation and retention (EPR) effect. This study offered a new strategy to design an ‘‘all-in-one’’ nanoplatform for T1/T2 MR imaging-guided synergistic cancer treatment of CDT/PTT

第一作者：陈潜,孙国英

论文类型：期刊论文

卷号：8

页面范围：1

ISSN号：2050-7518

是否译文：否

发表时间：2020-04-03