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Affiliation of Author(s):化学与生命科学学院
Teaching and Research Group:化学教研室
Journal:New Journal of Chemistry
Funded by:省、市、自治区科技项目
Abstract:The development of biocompatible theranostic agents with imaging and therapeutic function is urgently desired for biomedicine and nanoscience. Herein, a novel polydopamine (PDA) coated lanthanide-based nanocomposite NaGdF4:Dy@PDA-PEG-FA (NaGdF4:Dy@PPF) has been succesfully constructed for early diagnosi and treatment of tumors. MTT assay, histological analysis and the body weight changes of mice unambiguously revealed that this agent had relatively low cytotoxicity and negligible tissue damage. Due to the strong NIR absorption of PDA, this nanocomposite could be triggered effectively by 808 nm laser irradiation to produce an excellent photothermal conversion efficiency of 32.3%. Furthermore, NaGdF4:Dy@PPF displayed high longitudinal (r1 = 1.27 mM-1 s-1) and transverse (r2 = 126.0 mM-1 s-1) relaxivities, and strong X-ray attenuation characteristic (43.56 HU L g-1). And T1/T2-weighted MRI and CT imaging in vivo confirmed that this nanocomposite could induce significant contrast-enhancement effect on tumor site at 24 h post injection. In addition, NaGdF4:Dy@PPF showed outstanding photothermal cytotoxicity against 4T1 cells and efficient inhibition of tumor growth under 808 nm irradiation. All these results demonstrated that this multifunctional nanoplatform had potential application as a novel multimodal imaging-guided PTT agent for early diagnosis and therapy of tumors.
First Author:sunguoying
Indexed by:Journal paper
Volume:43
Page Number:1
ISSN No.:1369-9261
Translation or Not:no
Date of Publication:2019-04-10