【SCI1区通讯作者宋晓峰】A drug-loaded amphiphilic polymer/poly(L-lactide) shape-memory system

Release time:2022-09-30  Hits:

• Affiliation of Author(s):化学工程学院
• Journal:International Journal of Biological Macromolecules
• Funded by:其他课题
• Abstract:Biodegradable shape-memory polymers (SMPs) which are functional materials with applicability for medicine devices are designed to acquire their therapeutically relevant shape and drug release after implantation. In the work, an amphiphilic polymer (PVAD) is synthesized by using polytetrahydrofuran (PTMG), vinyl acetate (VAc), acrylic acid (AA), tetramethyltetravinylcyclotetrasiloxane (D4vi) as raw materials. PVAD encapsulating hydrophilic drug as switching phase and poly(L-lactide) (PLLA) as fixing matrix construct an SM system with the characteristic of “reservoir-matrix” drug release. The shape recovery ratio (Rr) of medicated PVAD/PLLA reaches 99 % by heat-water stimulation. The effects of release temperature and SM on drug release are investigated. With the release temperature increasing, the medicated PVAD/PLLA accelerates drug release and shows burst release initially, while the drug release for the medicated PLLA changes slightly. The drug release rate goes up after 3 rounds of SM. The mechanism of SM system controlling drug release is put forward based on structural changes.The yield strength and elongation at break of medicated PVAD/PLLA are 29.8 MPa and 44.6 %, respectively. It opens up new perspectives for drug carrier matrices in Pharmaceutical Sciences.
• Co-author:任亚君,宋晓峰
• First Author:songxiaofeng
• Indexed by:Journal paper
• Volume:217
• Page Number:1
• Translation or Not:no
• Date of Publication:2022-07-26