A conductive anisotropic hydrogel based on carboxymethyl cellulose and polyvinyl alcohol for intelligent ligament scaffold

Release time:2026-06-22  Hits:

• Journal:Polymer
• Key Words:Conductive hydrogel, High-toughness, Intelligent ligament scaffold
• Abstract:The rapid advancements in conductive hydrogels have spurred their widespread application across diverse fields. How to transform conductive hydrogels into intelligent tissue scaffolds for repairing ligament remains a formidable challenge. In the work, a conductive anisotropic hydrogel scaffold was made from polyvinyl alcohol (PVA) and carboxymethyl cellulose (CMC) through combination of freezing-thawing, pre-stretching, annealing, and salt immersion. At the pre-stretching ratio of 1.2, the conductive hydrogel scaffold demonstrated good resistance to swelling and decrease in water content. The conductive hydrogel scaffold highlighted mechanical properties along orientation direction including a tensile strength of 26.24 MPa and a toughness of 51.95 MJ/m3. It still maintained mechanical stability and resistance to cyclic tensile fatigue even if being swollen in simulated physiological environments (SBF). Whether undergoing swelling or not, the conductive hydrogel scaffold presented favorable strain sensing, cyclic tensile sensing stability and self-powered detection capability. The swollen conductive hydrogel scaffold could real-time monitor various movement and self-fault prediction in SBF. And it was non-cytotoxic and had biomedical value. It provides a promising candidate for ligament defect treatment and establishes a platform of developing intelligent tissue engineering material.
• Co-author:王兴芸
• First Author:宋晓峰（教师）
• Indexed by:Journal paper
• Volume:344
• Page Number:129477
• Translation or Not:no
• Date of Publication:2026-01-01
• Included Journals:SCI

• 1.2026-polymer1.pdf