Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
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Affiliation of Author(s):化学与生命科学学院
Teaching and Research Group:生物技术教研室
Journal:Nano Research
Funded by:国家自然科学基金项目
Key Words:nanomaterials, facet, metal dissolution, safe-by-design, toxicity
Abstract:The particular physicochemical properties of nanomaterials are able to elicit unique biological responses. The property activity relationship is usually established for in-depth understanding of toxicity mechanisms and designing safer nanomaterials. In this study, the toxic role of specific crystallographic facets of a series of polyhedral lead sulfide (PbS) nanocrystals, including truncated octahedrons, cuboctahedrons, truncated cubes, and cubes, was investigated in human bronchial epithelial cells (BEAS-2B) and murine alveolar macrophages (RAW 264.7) cells. {100} facets were found capable of triggering facet-dependent cellular oxidative stress and heavy metal stress responses, such as glutathione depletion, lipid peroxidation, reactive oxygen species (ROS) production, heme oxygenase-1 (HO-1) and metallothionein (MT) expression, and mitochondrial dysfunction, while {111} facets remained inert under biological conditions. The {100}-facet-dependent toxicity was ascribed to {100}-facet-dependent lead dissolution, while the low lead dissolution of {111} facets was due to the strong protection afforded by poly(vinyl pyrrolidone) during synthesis. Based on this facet-toxicity relationship, a “safe-by-design” strategy was designed to prevent lead dissolution from {100} facets through the formation of atomically thin lead-chloride adlayers, resulting in safer polyhedral PbS nanocrystals
First Author:li xi
Indexed by:Journal paper
Volume:9
Issue:12
Page Number:2
ISSN No.:1998-0124
Translation or Not:no
Date of Publication:2016-08-04
